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Triclonal gammopathy (IgAk, IgGk, and IgMk) in a patient with plasmacytoid lymphoma derived from a monoclonal origin
Author(s) -
Murata Takashi,
Fujita Hiroyuki,
Harano Hiroshi,
Hukawa Masaya,
Kanamori Heiwa,
Matsuzaki Michio,
Mohri Hiroshi,
Kudoh Jun,
Shimizu Nobuyoshi,
Okubo Takao
Publication year - 1993
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830420213
Subject(s) - serum protein electrophoresis , kappa , lymphoma , antibody , clone (java method) , immunoelectrophoresis , gammopathy , paraproteinemias , pathology , medicine , microbiology and biotechnology , immunoglobulin gene , monoclonal gammopathy , waldenstrom macroglobulinemia , monoclonal , immunoglobulin a , monoclonal antibody , immunology , biology , immunoglobulin g , gene , genetics , linguistics , philosophy
We report the case of a 64‐year‐old woman with plasma cytoid lymphoma of the ileum and gastric wall. Serum protein electrophoresis and immunoelectrophoresis showed a triclonal IgGk, IgAk, and IgMk gammopathy. Biopsy of the tumor revealed three different cell types, which were stained with antibodies specific for IgG, IgA, and IgM. However, DNA analysis of immunoglobulin gene rearrangements using J H , C μ , and C k gene probes showed a monoclonal pattern. These results suggest that the three types of malignant cells producing different classes of immunoglobulins were derived from a single clone of B‐cells that had undergone a “class switch”. © 1993 Wiley‐Liss, Inc.