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Autoimmune neutropenia following peripheral blood stem cell transplantation
Author(s) -
Klumpp Thomas R.,
Herman Jay H.,
Macdonald John S.,
Schnell Maryann K.,
Mullaney Mark,
Mangan Kenneth F.
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830410313
Subject(s) - medicine , neutropenia , transplantation , splenectomy , lymphoma , granulocyte colony stimulating factor , immunology , autologous stem cell transplantation , bone marrow , absolute neutrophil count , differential diagnosis , rituximab , chemotherapy , pathology , spleen
The differential diagnosis of unexpected neutropenia following bone marrow transplantation includes several potentially life‐threatening complications including graft rejection, overwhelming infection, relapse of the underlying neoplasm, and intrinsic graft failure. However, a number of recent reports document that the differential diagnosis also includes autoimmune neutropenia, which, although potentially life‐threatening, often responds well to corticosteroids or splenectomy. Autoimmune neutropenia has been reported following both autologous and allogeneic bone marrow transplantation. Herein we report a 31‐year‐old woman who developed a rapidly falling neutrophil count 11 days following peripheral blood stem cell transplantation for non‐Hodgkin's lymphoma. A laboratory evaluation supported a diagnosis of autoimmune neutropenia, and the neutropenia resolved following treatment with steroids and granulocyte‐colony stimulating factor. © 1992 Wiley‐Liss, Inc.