A new case of acute lymphoblastic leukemia B‐cell type with chromosomal rearrangements involving the T‐cell receptor breakpoint at band 14q11 | Zendy

Cigudosa J. C. | Zendy; Calasanz M. J. | Zendy; Gullón A. | Zendy; Prósper F. | Zendy; Cuesta B. | Zendy; Rifón J. | Zendy; Rocha E. | Zendy

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A new case of acute lymphoblastic leukemia B‐cell type with chromosomal rearrangements involving the T‐cell receptor breakpoint at band 14q11

Author(s) -

Cigudosa J. C.,

Calasanz M. J.,

Gullón A.,

Prósper F.,

Cuesta B.,

Rifón J.,

Rocha E.

Publication year - 1992

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830410213

Subject(s) - chromosomal translocation , breakpoint , t cell receptor , biology , locus (genetics) , leukemia , t cell , lymphoblastic leukemia , gene rearrangement , gene , cell , cancer research , genetics , microbiology and biotechnology , immune system

A patient with B‐cell acute lymphoblastic leukemia (ALL) and a translocation t(8;14) (q24;q11) is described. Translocation t(8;14)(q24;q32) is commonly associated with B‐cell leukemia; nevertheless, translocations affecting chromosome 14 at band q11 are associated with T‐cell malignancies, since the locus 14q11 contains genes that encode for the α and δ chains of the T‐cell receptor (TCR). This finding points to the idea that the association between 14q11 rearrangements and T‐cell neoplasia is less than complete. © 1992 Wiley‐Liss, Inc.

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