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A new case of acute lymphoblastic leukemia B‐cell type with chromosomal rearrangements involving the T‐cell receptor breakpoint at band 14q11
Author(s) -
Cigudosa J. C.,
Calasanz M. J.,
Gullón A.,
Prósper F.,
Cuesta B.,
Rifón J.,
Rocha E.
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830410213
Subject(s) - chromosomal translocation , breakpoint , t cell receptor , biology , locus (genetics) , leukemia , t cell , lymphoblastic leukemia , gene rearrangement , gene , cell , cancer research , genetics , microbiology and biotechnology , immune system
A patient with B‐cell acute lymphoblastic leukemia (ALL) and a translocation t(8;14) (q24;q11) is described. Translocation t(8;14)(q24;q32) is commonly associated with B‐cell leukemia; nevertheless, translocations affecting chromosome 14 at band q11 are associated with T‐cell malignancies, since the locus 14q11 contains genes that encode for the α and δ chains of the T‐cell receptor (TCR). This finding points to the idea that the association between 14q11 rearrangements and T‐cell neoplasia is less than complete. © 1992 Wiley‐Liss, Inc.