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Elevated neutrophil function in chronic neutrophilic leukemia
Author(s) -
Ohtsuki Tetsuya,
Mizukami Hiroaki,
Kimura Fumihiko,
Ohnishi Mayumi,
Nagata Naokazu,
Motoyoshi Kazuo,
Katsura Yoshiya,
Matsuura Yoshifusa
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830410110
Subject(s) - medicine , leukemia , function (biology) , immunology , biology , genetics
A 65‐year‐old man with marked leukocytosis was admitted for diagnosis and treatment. His peripheral blood leukocyte count was 37,500/μI and the leukocytes consisted of mature neutrophil‐like cells. A high neutrophil alkaline phosphatase score and a normal bone marrow cell karyotype suggested that the patient had chronic neutrophilic leukemia rather than chronic myeloid leukemia. Several neutrophil functions, such as superoxide production, nitroblue tetrazolium reduction activity, and phagocytosis, were elevated. These data and the morphological features (toxic granules and Döhle bodies) indicated that the patient's neutrophils were in an activated stage. © 1992 Wiley‐Liss, Inc.