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Plasma cytokine levels in thrombotic thrombocytopenic purpura
Author(s) -
Wada Hideo,
Kaneko Toshihiro,
Ohiwa Michiaki,
Tanigawa Motoaki,
Tamaki Shigehisa,
Minami Nobuyuki,
Takahashi Hoyu,
Deguchi Katsumi,
Nakano Takeshi,
Shirakawa Shigeru
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400303
Subject(s) - thrombotic thrombocytopenic purpura , medicine , cytokine , immunology , platelet
Plasma cytokine levels were examined in 13 patients with thrombotic thrombocytopenic purpura (TTP). Auto‐antibodies, platelet‐associated immunoglobulin G, and platelet aggregating factor were detected in many of these patients and high‐molecular‐weight bands of von Willebrand factor multimers were reduced in 9 of 10 patients examined. Complete remission (CR) was attained in 7 of the 13 patients, but 6 died. Tumor necrosis factor (TNF), Interleukin (IL)‐1β, IL‐6, and soluble IL‐2 receptor showed marked increases at onset and decreased at CR. The prognosis tended to be poor in patients with increased IL‐6 and soluble IL‐2 receptor levels. These findings suggest that immunological mechanisms, such as the activation of macrophage, are involved in the pathogenesis of TTP and are reflected in the plasma cytokine levels. © 1992 Wiley‐Liss, Inc.