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Bound vitamin B 12 absorption in patients with low serum B 12 levels
Author(s) -
Miller Aaron,
Furlong David,
Burrows Belton A.,
Slingerland D. Ward
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400302
Subject(s) - absorption (acoustics) , intrinsic factor , vitamin b , medicine , chemistry , endocrinology , vitamin , vitamin b12 , materials science , composite material
Abstract In many patients with low serum levels of vitamin B 12 , the absorption of the free vitamin has been normal. The present study, using a total body counter 57 CoB 12 absorption method that clearly separated those with intrinsic factor deficiency from controls, found that of 94 patients with low B 12 levels and intact stomachs in whom the absorption of free and bound B 12 was determined, 44 (47%) had normal absorption of both. However, 20 of the 94 (21%) with normal absorption of free B 12 had low absorption of bound B 12 . The remainder (32%) had low absorption of both free and bound B 12 . All patients with high serum gastrin levels had low bound B 12 absorption, but so did 21% of those patients with normal serum gastrin levels. © 1992 Wiley‐Liss, Inc.