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Acquired von willebrand disease: Correction of hemostatic defect by high‐dose intravenous immunoglobulins
Author(s) -
Delmer A.,
Horellou M. H.,
Bréchot J. M.,
Prudent J.,
Potevin F.,
Lecrubier C.,
GirardLonghini C.,
Samama M.,
Zittoun R.
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400214
Subject(s) - medicine , von willebrand factor , von willebrand disease , antibody , hemostasis , intravenous immunoglobulins , gastroenterology , surgery , immunology , platelet
Abstract High‐dose intravenous immunoglobulins (ivIG) were used in a 57‐year‐old patient with acquired von Willebrand disease in order to correct a hemostatic defect before pneumonectomy for lung carcinoma. IvIG induced a rapid and complete correction of factor VIII (F VIII) and von Willebrand factor (vWF) and allowed surgery without additional factor coverage. F VIII and vWF returned to baseline values within 10 days after ivIG. © 1992 Wiley‐Liss, Inc.