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Effect of red blood cells from patients with sickle cell disease on platelet factor 3 release
Author(s) -
Toumbis Constantine A.,
Stadler Istvan,
Ambrus Julian L.
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400213
Subject(s) - platelet , pentoxifylline , red cell , red blood cell , blood cell , hypoxia inducible factors , genotype , platelet activation , hypoxia (environmental) , cell , medicine , immunology , coagulation , endocrinology , chemistry , biochemistry , oxygen , gene , organic chemistry
Red cells from two SS genotype and two SA genotype patients were sampled. When the samples were deoxygenated and mixed with platelet‐rich plasma, they caused the release of platelet factor 3 as recorded in a coagulometer. This phenomenon was not present in control blood samples from normal individuals. Membrane changes in abnormal red cells during hypoxia may be responsible in part for platelet activation and its role in vasoocclusive crisis. Vasoocclusive crisis could be prevented by increasing the red cell membrane fluidity and inhibiting the platelet aggregation with pentoxifylline. © 1992 Wiley‐Liss, Inc.