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Cephalosporin‐induced hemolysis: A case report and review of the literature
Author(s) -
Ehmann W. Christopher
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400209
Subject(s) - hemolysis , cephalosporin , hemolytic anemia , medicine , red blood cell , red cell , haptoglobin , hapten , immunology , immune system , cefotetan , antibody , antibiotics , microbiology and biotechnology , biology , antibiotic resistance , imipenem
Cephalosporins are commonly used drugs that interact with red blood cell membranes. They frequently cause a positive direct antiglobulin test but rarely cause hemolysis. A case of cefotetan‐induced hemolytic anemia is described in which two types of antibodies were detected. One reacted with red blood cells by a hapten mechanism, the other reacted with drug to form immune complexes. This case is compared with the 13 cases of cephalosporin‐induced hemolytic anemia reported to date. Understanding the interactions of red blood cells and cephalosporins is critical to the safe use of these commonly prescribed drugs. © 1992 Wiley‐Liss, Inc.