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Clinical relevance of immunological dissection in T‐ALL: A report on 20 cases with stem cell (CD7+, CD4‐, CD8‐, CD1‐) phenotype
Author(s) -
Ferrara Felicetto,
Cimino Renato,
Antinolfi Iolanda,
de Rosa Carlo,
Mele Giuseppina,
Mettivier Vincenzo,
Fusco Caterina,
Vecchio Luigi Del
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400205
Subject(s) - immunophenotyping , cd8 , leukemia , medicine , immunology , t cell , hematology , antigen , immune system
Abstract In a prospective study on 44 cases of T‐cell origin acute lymphoblastic leukemia, 20 patients were found to display an immature immunophenotype (CD7+, CD4‐, CD8‐, CD1‐) and were classified as T‐stem cell leukemia (T‐SCL). Twenty‐four patients expressed CD4 and/or CD8 antigens on their blast cells, designated T acute lymphoblastic leukemia (T‐ALL). The T‐SCL subset showed a significantly higher median age, a more frequent incidence of extramedullary leukemia, a morphology L1 in most cases, and a poor response to treatment in terms of either complete remission rate or median survival duration. In addition, significant differences between the two groups were found in evaluating the number of days of blast disappearance from peripheral blood, of CR achievement, and of neutrophils and platelets recovery. We conclude that T‐SCL represents a distinct clinical entity, characterized by a poor response to ALL conventional chemotherapy. Alternative therapeutic approaches should be developed for patients suffering from this form of leukemia, to modify its severe prognosis. © 1992 Wiley‐Liss, Inc.