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Recombinant alpha‐interferon inhibits colony formation of bone marrow fibroblast progenitor cells (CFU‐F)
Author(s) -
Wang Jen C.,
Lang HongDao,
Liao Paul,
Wong Albert
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400202
Subject(s) - colony forming unit , progenitor cell , haematopoiesis , megakaryocyte , bone marrow , cfu gm , granulocyte , microbiology and biotechnology , biology , fibroblast , interferon , alpha interferon , stem cell , macrophage , immunology , cell culture , in vitro , biochemistry , genetics , bacteria
Alpha‐Interferon (IFN‐α) has been shown to inhibit colony formation of hematopoietic progenitor cells, including colony‐forming unit‐granulocyte, erythroid, macrophage, megakaryocyte (CFU‐GEMM), day 7 colony‐forming unit granulocyte‐macrophage (CFU‐GM), day 14 CFU‐GM, burst‐forming unit erythroid (BFU‐E), pluripotent stem cells (CFU‐S), and colony‐forming unit megakaryocyte (CFU‐MK). The present study was designed to see whether IFN‐α also has inhibitory effects on bone marrow fibroblast progenitors (CFU‐F). We found that IFN‐α exerted a significant inhibitory effect on both rabbit and human CFU‐F formation. Inhibition of human marrow CFU‐F formation by alpha interferon was unaffected by removal of 98% of monocytes/macrophages and T lymphocytes from light density marrow cells. This finding suggests that IFN‐α probably exerts a direct inhibitory effects. © 1992 Wiley‐Liss, Inc.