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Abnormalities in immune regulation precede the development of multiple myeloma
Author(s) -
Paglieroni Teresa,
Caggiano Vincent,
Mackenzie Malcolm
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400111
Subject(s) - multiple myeloma , immunosuppression , immune system , hematological malignancy , malignancy , immunology , cd5 , antibody , myeloma protein , medicine
Immunosuppression of immunoglobulin synthesis seen in patients with multiple myeloma is in part due to immunosuppressive CD5 positive B cells. In a 13 year longitudinal study of an IgA‐deficient blood donor who developed multiple myeloma, the presence of immunosuppressive CD5 positive B cells and T cells preceded the diagnosis of overt multiple myeloma and the appearance of immunosuppressive monocytes. These data argue that certain immune defects may be involved in the development of myeloma and are not simply a consequence of overt malignancy. © 1992 Wiley‐Liss, Inc.