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Hereditary factor VII deficiency in pregnancy: Peripartum treatment with factor VII concentrate
Author(s) -
Robertson L. E.,
Wasserstrum Nathan,
Banez Eugenio,
Vasquez Maria,
Sears David A.
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830400108
Subject(s) - medicine , fresh frozen plasma , pregnancy , risk factor , factor vii , postpartum bleeding , edema , obstetrics , surgery , platelet , coagulation , genetics , biology
This report describes pregnant sisters with severe factor VII deficiency and peripartum management with factor VII concentrate. In this family, two affected members had previously developed severe postpartum hemorrhage when managed with fresh frozen plasma. Therapy‐related complications owing to plasma infusion included viral disease transmission and pulmonary edema. Therefore, to lessen the risks of complications, specific factor therapy was initiated shortly before parturition in both patients. Factor VII concentrate was administered prior to delivery and every 6 hr for the next 72 hr to keep trough levels at approximately 10%. Based on peak and trough levels, the mean factor VII half‐lives were determined to be 3.6 and 5.7 hr. Use of the concentrate was associated with uncomplicated delivery and minimal postpartum bleeding. © 1992 Wiley‐Liss, Inc.