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Human parvovirus B19 infection in hemophiliacs first infused with two high‐purity, virally attenuated factor Vlll concentrates
Author(s) -
Azzi A.,
Ciappi S.,
Zakvrzewska K.,
Morfini M.,
Mariani G.,
Mannucci P. M.
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830390315
Subject(s) - parvovirus , seroconversion , virology , medicine , coagulation , virus , transmission (telecommunications) , electrical engineering , engineering
Human parvovirus B19 can be transmitted by coagulation factor concentrates and is highly resistant to virucidal methods. To evaluate whether the additional removal of virus by chromatographic methods during the manufacture of high‐purity concentrates re‐duces the risk of B19 transmission, we have prospectively evaluated the rate of anti‐B19 seroconversion in two groups of susceptible (anti‐B19 negative) hemophiliacs infused with high‐purity, heated (pasteurized) or solvent‐detergent‐treated factor Vlll concen‐ trates. Both products infected a relatively high proportion of patients (nine of 20).