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Fluctuations in serum cytokine levels in the patient with cyclic neutropenia
Author(s) -
Yujiri T.,
Shinohara K.,
Kurimoto F.
Publication year - 1992
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830390214
Subject(s) - cyclic neutropenia , neutropenia , medicine , cytokine , immunology , chemotherapy
The fluctuations of the levels of serum cytokines in a patient with cyclic neutropenia were studied. The greatest fluctuation was found in granulocyte colony‐stimulating factor (G‐CSF). Tumor necrosis factor‐α level fluctuated inversely with fluctuation of G‐CSF, and oscillation of interleukin (IL)‐6 level preceded that in G‐CSF level. It is likely that the variations of the levels of cytokines play a significant role in regulating hematopoiesis in cyclic neutropenia. Our results suggested that the stage of the granulocyte‐committed stem cell is the major step of the defect, and the defect at the stage of the multipotent stem cell or bone marrow microenvironment was also suggested.