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Hemophagocytic syndrome associated with aggressive natural killer cell leukemia
Author(s) -
Okuda Tsukasa,
Sakamoto Shinichi,
Deguchi Takeshi,
Misawa Shinichi,
Kashima Kei,
Yoshihara Takao,
Ikushima Satoshi,
Hibi Shigeyoshi,
Imashuku Shinsaku
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380412
Subject(s) - hemophagocytosis , immunology , leukemia , bone marrow , medicine , cytokine , natural killer cell , biology , pancytopenia , cytotoxic t cell , biochemistry , in vitro
We describe a patient who had aggressive natural killer cell leukemia with profound hemophagocytosis. This combination must be underscored as one of several hemophagocytic syndromes. Activated phagocytes in the bone marrow appeared morphologically normal and could possibly be proliferating in response to some cytokine(s) such as interferon‐gamma produced by leukemic cells, whose serum level was found to be extremely elevated in this case.