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Plasma levels of soluble thrombomodulin increase in cases of disseminated intravascular coagulation with organ failure
Author(s) -
Asakura Hidesaku,
Jokaji Hiroshi,
Saito Masanori,
Uotani Chika,
Kumabashiri Ichiro,
Morishita Eriko,
Yamazaki Masahide,
Matsuda Tamotsu
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380406
Subject(s) - thrombomodulin , disseminated intravascular coagulation , medicine , sepsis , pathology , immunology , gastroenterology , thrombin , platelet
Abstract We examined the changes in plasma levels of soluble thrombomodulin in 66 cases of disseminated intravascular coagulation (DIC), to investigate the damage to vascular endothelial cells and its relationship to multiple organ failure. A significant elevation of plasma levels of soluble thrombomodulin was observed in most cases of DIC, especially in patients with sepsis. However, no such significant elevation was observed in patients with acute promyelocytic leukemia. Plasma levels of both soluble thrombomodulin and active plasminogen activator inhibitor were higher in the cases of DIC with multiple organ failure than in those without multiple organ failure. The levels of soluble thrombomodulin were decreased with the clinical improvement in most cases of DIC but were further increased or remained at high levels in patients who showed no improvement of DIC. It was suggested that an increase in soluble thrombomodulin indicates the damage to the vascular endothelial cells in cases of DIC and that the damage to vascular endothelial cells plays some role in further progression of multiple organ failure.