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Epirubicin and cytosine arabinoside for the induction therapy of childhood acute nonlymphocytic leukemia
Author(s) -
Liang DerCherng,
Jiang ChangJen
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380403
Subject(s) - epirubicin , anthracycline , medicine , cytosine , leukemia , cytarabine , chemotherapy , daunorubicin , gastroenterology , immunology , oncology , cyclophosphamide , cancer , biology , dna , breast cancer , genetics
Epirubicin, a new anthracycline, was used in combination with cytosine arabinoside for the induction therapy of de novo acute nonlymphocytic leukemia in childhood. The treatment consisted of epirubicin 20 mg/m 2 /day for 3 days and cytosine arabinoside 100 mg/m 2 /day for 7 days. The treatment could be repeated every 3 weeks. Remission induction rate was 80% (20/25). Moreover, in 13 patients, the remissions were obtained after a single course. In general, the side effects of epirubicin and cytosine arabinoside were tolerable. However, the main causes of all the three deaths were infections. Our study suggests that epirubicin is acceptable and effective for the induction therapy for de novo acute nonlymphocytic leukemia in childhood.