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Increased levels of tissue plasminogen activator with a low plasminogen activator inhibitor‐1 in a patient with postoperative bleeding
Author(s) -
Stankiewicz Andrzej J.,
Crowley James P.,
Steiner Manfred
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380314
Subject(s) - plasminogen activator , tissue plasminogen activator , plasminogen activator inhibitor 1 , medicine , activator (genetics) , fibrinolysis , gastroenterology , endocrinology , t plasminogen activator , surgery , receptor
Recurrent postoperative bleeding in a previously healthy man with a moderate prolongation of PT and PTT which did not correct with vigorous fresh‐frozen plasma infusion was identified as a unique abnormality of the fibrinolytic system: a combination of an excess of tissue plasminogen activator (t‐PA) at 300% of normal activity accompanied by a concurrent deficiency of plasminogen activator inhibitor‐1 activity (PAI‐1) of 10‐20% of normal activity. This observation underscores the potentially important regulatory role of PAI‐1 in the degree to which clinical manifestations of bleeding tendencies may occur in patients in whom an excess amount of t‐PA is expressed.