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Circulating thrombomodulin in thrombotic thrombocytopenic purpura
Author(s) -
Takahashi Hoyu,
Hanano Masaharu,
Wada Ken,
Tatewaki Wataru,
Niwano Hiroe,
Shibata Akira,
Tsubouchi Jiro,
Nakano Masahiko,
Nakamura Tadao
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380304
Subject(s) - thrombomodulin , thrombotic thrombocytopenic purpura , medicine , von willebrand factor , gastroenterology , immunology , endothelium , endothelial stem cell , endocrinology , platelet , thrombin , chemistry , biochemistry , in vitro
Endothelial cell injury is thought to be one of the causative factors in thrombotic thrombocytopenic purpura (TTP). A novel index of endothelial injury, plasma thrombomodulin, was measured in 13 patients with acute TTP. The mean plasma concentration of thrombomodulin was elevated in patients with TTP (34.23 ± 19.08 ng/ml) as compared with healthy subjects (16.99 ± 2.63 ng/ml, P <0.001). Eight (61.5%) of 13 patients had high thrombomodulin values. Markedly elevated thrombomodulin levels were observed in TTP patients who had suffered from systemic lupus erythematosus, in whom plasma thrombomodulin was still elevated when they achieved remission. Five of these 13 patients with TTP had normal plasma levels of thrombomodulin. In addition, the plasma thrombomodulin concentrations were correlated well with von Willebrand factor antigen and tissuetype plasminogen activator antigen levels, both of which are released from stimulated or damaged endothelial cells. No difference was found in plasma thrombomodulin levels between patients who achieved remission and who did not. These findings suggest that the magnitude of the endothelial damage in TTP is variable among patients and that plasma thrombomodulin has limited clinical relevance to the severity of TTP.