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Hyperammonemia following allogeneic bone marrow transplantation
Author(s) -
Tse Nielson,
Cederbaum Stephen,
Glaspy John A.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380213
Subject(s) - hyperammonemia , medicine , complication , chronic myelogenous leukemia , bone marrow , transplantation , chemotherapy , leukemia , surgery , gastroenterology
Hyperammonemia is a rare and serious complication of intensive cytotoxic chemotherapy. We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. The literature is reviewed, and recommendations for an approach to this complication of marrow transplantation are proposed.