Premium
Effect of estrogens and progesterone on human peripheral erythroid burst‐forming unit (BFU‐E) growth
Author(s) -
De Feo T. M.,
Cappellini M. D.,
Fiorelli G.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380202
Subject(s) - endocrinology , medicine , peripheral , in vitro , monocyte , hormone , menstrual cycle , peripheral blood , chemistry , biology , biochemistry
Variations in the number of peripheral burst‐forming unit—erythroid (BFU‐E) of healthy women were observed during a prolonged period of observation. These differences were related to different phases of the menstrual cycle. A peak in the number of BFU‐E occurred on day 14 of the cycle corresponding to the serum 17‐β‐estradiol peak. The effect of estrogens and progesterone on the in vitro growth of peripheral BFU‐E of healthy women was assayed. Estrogens demonstrated a stimulatory and progesterone an inhibitory effect in total lymphomonocyte cultures, whereas neither hormone had an effect in monocyte‐depleted cultures. Prostaglandin E 1 (PGE 1 ) which is known to be secreted by monocytes, stimulated the in vitro growth of peripheral BFU‐E. These data suggest that estrogens and progesterone could have a role in the in vitro growth of peripheral BFU‐E, probably mediated by monocytes.