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Unexpectedly high toxicity of MACOP‐B in young patients with low grade lymphoma
Author(s) -
Arranz R.,
Peréz G.,
Steegmann J. L.,
Cámara R.,
Tomás J. F.,
Figuera A.,
Vazquez L.,
FernándezRañada J. M.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380115
Subject(s) - medicine , neutropenia , lymphoma , complication , chemotherapy , toxicity , complete remission , surgery , gastroenterology
Abstract We report the results of treatment with MACOP‐B in 11 young patients with low grade lymphoma (LGL). Complete remission was obtained in 4 (57%) and partial remission in 3 (42.8%) of 7 evaluable patients. However, this aggressive chemotherapy has not offered any advantage because of an unacceptably high treatment‐related morbidity and mortality (17%). Serious infection during neutropenia was the most common complication.