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Transient reversal of bone marrow aplasia associated with lymphocyte depleted hodgkin's disease after combination chemotherapy
Author(s) -
Johnston P. G.,
Sullivan F. J.,
Ruscetti F. W.,
Longo D. L.,
Connaghan D. G.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830380109
Subject(s) - bone marrow aplasia , medicine , aplastic anemia , aplasia , chemotherapy , bone marrow , disease , bone marrow failure , pure red cell aplasia , pathology , haematopoiesis , stem cell , biology , genetics
This report describes a patient with lymphocyte depleted Hodgkin's disease who presented with bone marrow aplasia. The aplastic marrow reverted to normal after initiation of MOPP chemotherapy; however, 4 months after completion of therapy, bone marrow aplasia recurred in the absence of recurrent Hodgkin's disease. The patient remains free of Hodgkin's disease 34 months after completion of chemotherapy. Bone marrow abnormalities in Hodgkin's disease are reviewed and the current understanding of the pathological mechanisms leading to aplastic anemia is discussed.