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Usefulness of electron microscopy in the diagnosis of congenital dyserythropoietic anemia type I: Report of a case
Author(s) -
Facon T.,
Zandecki M.,
Caulier M. T.,
Mannessier L.,
Fenaux P.,
Jouet J. P.,
Bauters F.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830370414
Subject(s) - macrocytic anemia , anemia , electron microscope , bone marrow , microscopy , pathology , medicine , bone marrow examination , pediatrics , physics , optics
This report describes a case of congenital dyserythropoietic anemia (CDA) type I diagnosed in a 22‐year‐old woman with a two year history of macrocytic anemia. Light microscopy study of bone marrow disclosed only minor and nonspecific findings, without erythroid hyperplasia. Electron microscopy of bone marrow erythroblasts surprisingly showed most of the classical features of CDA type I. Electron microscopy may be an important tool for the diagnosis of macrocytic anemia of obscure origin, especially in young patients.