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Granulocyte‐macrophage colony stimulating factor for the treatment of drug induced agranulocytosis
Author(s) -
Nand Sucha,
Bayer Robert,
Prim Richard A.,
Felten William,
Godwin John E.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830370411
Subject(s) - medicine , granulocyte macrophage colony stimulating factor , granulocyte macrophage colony stimulating factor receptor , drug , granulocyte , immunology , granulocyte colony stimulating factor , pharmacology , macrophage , macrophage colony stimulating factor , chemotherapy , cytokine , biology , in vitro , biochemistry
Drug induced agranulocytosis is an uncommon but potentially fatal complication. In some cases, it may be associated with hypoplasia and depletion of granulocytic precursors in the marrow, leading to prolonged neutropenia. We report on the use of granulocytic‐macrophage colony stimulating factor (GM‐CSF) in two such cases, at a dose of 10 μg per kilogram per day subcutaneously. The absolute neutrophil count rose above 500/mm 3 in 3 days in both cases. We believe that GM‐CSF expedited the recovery of granulocyte counts in our patients and warrants further study in the management of drug induced neutropenia.