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Anticardiolipin antibodies (ACA) are most often not associated with lupus‐like anticoagulant (LLAC) in human immunodeficiency virus (HIV) infection
Author(s) -
Capel P.,
Janssens A.,
Clumeck N.,
Gerard M.,
Feremans W.,
Vandevelde D.,
Fondu P.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830370404
Subject(s) - lupus anticoagulant , partial thromboplastin time , medicine , antibody , immunology , common variable immunodeficiency , prothrombin time , systemic lupus erythematosus , anticardiolipin antibodies , gastroenterology , platelet , disease
Anticardiolipin antibodies (ACA) and lupus‐like anticoagulant (LLAC) have been studied in a group of 142 non‐hospitalized and a group of 72 hospitalized HIV infected patients. We observed a variable frequency of ACA positivity ranging from 7.7% to 30.3% according to the groups of patients and the isotype of immunoglobulin fraction containing ACA activity. None of the patients investigated presented a prolongation of the activated partial thromboplastin time (APTT) compatible with the presence of a LLAC. Some patients presented a weak anticoagulant activity only detected by the tissue thromboplastin inhibition (TTI) test. No positive correlation was found between this latter test and ACA. We conclude that, like in syphilitic patients, ACA present in HIV infected patients are most often not associated with LLAC.