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Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria
Author(s) -
Traore Ousmane,
Carnevale Pierre,
KaptueNoche Lazar,
M'Bede Joseph,
Desfontaine Michel,
Elion Jacques,
Labie Dominique,
Nagel Ronald L.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830370316
Subject(s) - parasitemia , chloroquine , plasmodium falciparum , malaria , medicine , pharmacology , in vitro , deferoxamine , immunology , virology , biology , biochemistry
The administration of 0.5 g (IM) of desferrioxamine every 12 hr for 3 days with 25 mg/kg (total dose for three days) of chloroquine abated the parasitemia of Plasmodium falciparum infected individuals more rapidly than chloroquine alone. Two patients with in vitro evidence of total or partial resistance to chloroquine also were successfully treated with the combination of drugs, and were free of parasitized red cells by day 7. Further clinical trials and development of desferrioxamine in the treatment of P. falciparum are warranted.