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Plasma adenosine deaminase 2 , is a marker for human immunodeficiency virus‐1 seroconversion
Author(s) -
Niedzwicki John G.,
Mayer Kenneth H.,
Abushanab Elie,
Abernethy Darrell R.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830370303
Subject(s) - seroconversion , asymptomatic , medicine , adenosine deaminase , immunology , viral disease , immunopathology , human immunodeficiency virus (hiv) , disease , virology , gastroenterology , adenosine
Plasma adenosine deaminase 2 , (ADA 2 ) has recently been proposed to be a marker for human immunodeficiency virus‐1 (HIV) infection. We measured ADA 2 , levels in plasma from two groups of white homosexual males at 6‐month intervals for a total of 2.5 years. One group consisted of 6 subjects who seroconverted for HIV, and the other consisted of 8 HIV seropositive patients who progressed from asymptomatic (CDC Groups II/III) to symptomatic (CDC Group IV) disease. Seroconversion was associated with a significant increase in plasma ADA 2 which persisted throughout follow‐up of 1.5 years. However, disease progression in HIV seropositive patients was not associated with any significant change in plasma ADA 2 In conclusion, ADA 2 , may represent a unique marker for HIV seroconversion which does not change with later progression to symptomatic disease.