Recombinant human erythropoietin for a Jehovah's witness with anemia of thermal injury | Zendy

Boshkov Lynn K. | Zendy; Tredget Edward E. | Zendy; JanowskaWieczorek Anna | Zendy

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Recombinant human erythropoietin for a Jehovah's witness with anemia of thermal injury

Author(s) -

Boshkov Lynn K.,

Tredget Edward E.,

JanowskaWieczorek Anna

Publication year - 1991

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830370113

Subject(s) - erythropoietin , reticulocyte , medicine , anemia , recombinant dna , endogeny , hemoglobin , blood transfusion , erythropoiesis , pharmacology , immunology , biology , biochemistry , messenger rna , gene

We report the use of recombinant human erythropoietin (rh‐Ep) as an alternative to transfusion therapy in a burn victim who was a Jehovah's Witness and refused blood transfusion. Despite endogenous elevated erythropoietin levels, the patient was reticulocytopenic and administration of rh‐Ep was accompanied by a 10‐fold increase in reticulocyte response and a rise in hemoglobin from 7.4 to 10.4 g/dl over a 12‐day period. We suggest that the exogenously administered erythropoietin overcame a clinically inadequate endogenous erythropoietin response.

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