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Myelodysplastic transformation of polycythemia vera: Case report and review of the literature
Author(s) -
Shamdas Glenn J.,
Spier Catherine M.,
List Alan F.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830370110
Subject(s) - polycythemia vera , immunophenotyping , medicine , myelodysplastic syndromes , refractory anemia , anemia , cytogenetics , immunology , bone marrow , biology , genetics , flow cytometry , chromosome , gene
We report a case of refractory anemia with excess blasts (RAEB) developing in a 67‐year old man with a history of polycythemia vera; results of cytogenetic and immunophenotyping studies are described. In this report the clinical, cytogenetic and hematologic features of myelodysplasia complicating polycythemia vera are reviewed. Results of immunophenotyping and cytogenetic studies, and the preponderance of cases developing after myelosuppressive therapy suggest that in the majority of cases myelodysplasia is treatment‐related.