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Detection of primary epstein‐barr virus infection in a patient with x‐linked lymphoproliferative disease receiving immunoglobulin prophylaxis
Author(s) -
Okano Motohiko,
Bashir Rifaat M.,
Davis Jack R.,
Purtilo David T.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830360416
Subject(s) - lymphoproliferative disease , medicine , antibody , epstein–barr virus , immunology , lymphoproliferative disorders , virus , immunoglobulin g , disease , immunoglobulin m , immunoglobulin a , virology , lymphoma
Serologic diagnosis for Epstein‐Barr virus (EBV) infection is problematic when patients receive exogenous immunoglobulin. We recently diagnosed primary EBV infection by detecting EBV‐determined nuclear antigen (EBNA) and EBV‐DNA in peripheral blood mononuclear cells (PBMC) using immunofluorescence, in situ hybridization and polymerase chain reaction (PCR) techniques in a patient with X‐linked lymphoproliferative disease (XLP) who received prophylactic immunoglobulins for EBV infection. These combined techniques may be helpful for early and accurate diagnosis of EBV infection in highly vulnerable patients.