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Case report: Interleukin‐6 positive follicular hyperplasia in the lymph node of a patient with rheumatoid arthritis
Author(s) -
Numata Yukiko,
Matsuura Yasushi,
Onishi Saburo,
Yamamoto Yasutake,
Ohno Fumitoshi,
Tagoh Hiromi,
Yoshizaki Kazuyuki,
Fujimoto Shigeyoshi,
Yamamoto Hiroshi
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830360412
Subject(s) - rheumatoid arthritis , medicine , hyperplasia , follicular phase , follicular hyperplasia , lymph node , pathology , immunology
We examined interleukin‐6 production in the hyperplastic lymph node of a 77‐year‐old male rheumatoid arthritis patient with lymphadenopathy. The interleukin‐6 production of the lymph node was observed by both immunohistological staining and in vitro culture. The results suggest that interleukin‐6 plays a significant pathogenic role in the etiology of the lymphadenopathy seen in many rheumatoid arthritis patients.