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Heparin‐induced thrombocytopenia and thrombosis: Reversal with streptokinase a case report and review of literature
Author(s) -
Mehta Daksha P.,
Yoder Ernest L.,
Appel Joel,
Bergsman Kenneth L.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830360410
Subject(s) - streptokinase , heparin induced thrombocytopenia , heparin , medicine , thrombosis , complication , venous thrombosis , surgery , incidence (geometry) , vascular disease , myocardial infarction , physics , optics
Abstract Heparin‐induced thrombocytopenia and thrombosis is associated with a significant incidence of morbidity and mortality. Prompt recognition of this complication and immediate withdrawal of heparin therapy are imperative. This report describes a case of heparin‐induced thrombosis and thrombocytopenia with major vascular insufficiency of the extremities. This is the first reported instance of the use of intravenous streptokinase for the treatment of heparin‐induced venous thrombosis.