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GM‐CSF‐mediated impairment of liver to synthesize albumin, cholinesterase, and cholesterol
Author(s) -
Takahashi Masuhiro,
Nikkuni Kohji,
Moriyama Yoshiaki,
Shibata Akira
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830360312
Subject(s) - albumin , cholinesterase , medicine , endocrinology , cholesterol , aplastic anemia , serum albumin , bone marrow
Serum albumin, cholinesterase, and cholesterol were measured in ten patients with aplastic anemia and eight with myelodysplastic syndrome who received the administration of recombinant human GM‐CSF. Serum albumin, cholinesterase, and cholesterol were significantly lowered by the administration of GM‐CSF and recovered after the cessation of GM‐CSF. These data suggest that GM‐CSF impairs the biosynthesis of liver cells and that cholesterol‐lowering activity of GM‐CSF, which is previously reported, is due to the impairment of liver biosynthesis by GM‐CSF.