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Helper‐suppressor T‐cell leukemia: Unusual phenotype controlled with low‐dose deoxycoformycin
Author(s) -
Adler Mark J.,
Hershberg Robert,
Yu Alice
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830360310
Subject(s) - deoxycoformycin , leukemia , phenotype , medicine , hairy cell leukemia , lymphocyte , cancer research , cell , suppressor , immunology , t cell leukemia , biology , cancer , adenosine , genetics , adenosine deaminase , gene
Presented is an unusual case of chronic T‐cell leukemia. Immunophenotypic profile revealed the leukemia cells to express T4 and T8 surface markers simultaneously. The patient was treated with low‐dose deoxycoformycin and control of symptoms and lymphocyte levels shown to correlate with ADA and dATP/ATP levels.