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Danazol therapy for cyclic thrombocytopenia
Author(s) -
Rocha Rafael,
Horstman Lawrence,
Ahn Yeon S.,
Mylvaganam Ravindra,
Harrington William J.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830360213
Subject(s) - danazol , medicine , platelet , splenectomy , gastroenterology , azathioprine , refractory (planetary science) , surgery , spontaneous remission , disease , endometriosis , pathology , alternative medicine , physics , spleen , astrobiology
Abstract Cyclic thrombocytopenia is a rare disease characterized by cyclic oscillations of platelet counts from very low to normal or higher. Severe hemorrhage may occur during the thrombocytopenic phase. To date, treatments for this disorder have been disappointing. Its pathophysiology is unknown. We report a successful outcome using danazol therapy. It can be argued that the long‐term outcome was due to spontaneous remission. However, significant improvement was noted from the outset of danazol therapy, and further improvement with long‐term therapy, as seen in the response of chronic ITP to danazol therapy. Danazol may offer lasting benefit in cyclic thrombocytopenia.