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T‐lymphoid blast crisis in chronic myeloid leukemia
Author(s) -
Advani S. H.,
Malhotra H.,
Kadam P. R.,
Iyer R. S.,
Nanjangud G.,
Balsara B.,
Saikia T.,
Gopal R.,
Nair C. N.
Publication year - 1991
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830360204
Subject(s) - myeloid , myeloid leukemia , philadelphia chromosome , lineage (genetic) , stem cell , immunology , precursor cell , biology , t cell , lymph , cancer research , pathology , cell , medicine , chromosomal translocation , genetics , immune system , gene
Abstract Chronic myeloid leukemia (CML) is considered to be a pleuripotential stem cell disorder with the capacity to differentiate into myeloid, erythroid, megakaryocytic, and lymphoid cell lines. Consequently, blast crisis (BC) involving each of the above lineages has been well described. Among lymphoblastic crises, differentiation frequently occurs along B‐cell lineage. We report four patients of CML who terminated in T‐cell extramedullary BC in lymph nodes after a variable duration of chronic phase. The T‐lineage was established by characteristic cytochemical staining and reactivity with a panel of anti‐T‐cell monoclonal antibodies. All four cases were Philadelphia (Ph) chromosome positive and demonstrated the Ph chromosome and associated anomalies (extra Ph, +19) in the lymph nodes. Our data adds to the growing evidence that CML is a disorder of the common stem cell from which T, B, and myeloid precursors originate.