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Acute myocardial infarction, non‐bacterial thrombotic endocarditis, and disseminated intravascular coagulation in a severe hemophiliac
Author(s) -
Green David,
Snapper Howard,
AbuJawdeh Graziella,
Reddy Janardan
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830350314
Subject(s) - medicine , disseminated intravascular coagulation , myocardial infarction , thrombosis , autopsy , endocarditis , pneumonia , heparin , coagulation , pulmonary embolism , cardiology
Thrombosis in hemophilia is very rare and is usually associated with the administration of prothrombin complex concentrates. We describe a severe hemophiliac with P. carinii pneumonia who had clinical and laboratory evidence of acute myocardial infarction and disseminated intravascular coagulation, and at autopsy, nonbacterial thrombotic endocarditis as well. We suggest that prothrombin complex concentrates should be used cautiously in the setting of acute infection, and perhaps be given with appropriate doses of anticoagulants such as heparin.