Neonatal alloimmune thrombocytopenic purpura associated with sensitization against the platelet‐specific antigen Yuk a | Zendy

Matsuda Tadashi | Zendy; Yonaha Hisashi | Zendy; Azuma Eiichi | Zendy; Sakurai Minoru | Zendy; Imai Shigemi | Zendy

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Neonatal alloimmune thrombocytopenic purpura associated with sensitization against the platelet‐specific antigen Yuk a

Author(s) -

Matsuda Tadashi,

Yonaha Hisashi,

Azuma Eiichi,

Sakurai Minoru,

Imai Shigemi

Publication year - 1990

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830350311

Subject(s) - neonatal alloimmune thrombocytopenia , antigen , immunology , platelet , thrombocytopenic purpura , medicine , antibody , hemagglutination , biology , pregnancy , fetus , genetics

We report a Japanese newborn who developed alloimmune thrombocytopenia by the antibodies to the newly discovered platelet antigen Yuk a . The infant recovered uneventfully in 10 days without specific treatment. Antiplatelet ailoantibodies in the patient were IgG class detected by mixed passive hemagglutination (MPHA). Family study showed that Yuk a antigen was inherited as an autosomal dominant trait. Cases with Yuk a ‐associated alloimmune thrombocytopenia are reviewed.

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