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Neonatal alloimmune thrombocytopenic purpura associated with sensitization against the platelet‐specific antigen Yuk a
Author(s) -
Matsuda Tadashi,
Yonaha Hisashi,
Azuma Eiichi,
Sakurai Minoru,
Imai Shigemi
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830350311
Subject(s) - neonatal alloimmune thrombocytopenia , antigen , immunology , platelet , thrombocytopenic purpura , medicine , antibody , hemagglutination , biology , pregnancy , fetus , genetics
We report a Japanese newborn who developed alloimmune thrombocytopenia by the antibodies to the newly discovered platelet antigen Yuk a . The infant recovered uneventfully in 10 days without specific treatment. Antiplatelet ailoantibodies in the patient were IgG class detected by mixed passive hemagglutination (MPHA). Family study showed that Yuk a antigen was inherited as an autosomal dominant trait. Cases with Yuk a ‐associated alloimmune thrombocytopenia are reviewed.