Premium
Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia
Author(s) -
Chang James,
Coutinho L. H.,
Dexter Michael,
Craft Alan W.,
Reid Michael M.
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830350212
Subject(s) - neutropenia , congenital neutropenia , bone marrow , progenitor cell , medicine , clonogenic assay , immunology , myeloid , bone marrow transplantation , in vitro , biology , chemotherapy , stem cell , microbiology and biotechnology , genetics
Severe congenital neutropenia has a poor outlook. In vitro clonogenic assays using recombinant growth factors may improve understanding of the underlying pathogenetic mechanisms and identify those in whom growth factors might be clinically useful. Marrow from a boy with congenital neutropenia was cultured with a variety of recombinant growth factors. The results show that the neutropenia did not result from a lack of myeloid progenitors but that these progenitors could not produce mature neutrophils. Bone marrow transplantation is being considered as the most likely approach to correct neutropenia.