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Prolymphocytic leukemia treated with natural and recombinant α‐interferon
Author(s) -
Terashima Takeshi,
Ohtake KenIchi,
Ogawa Tetsuhei
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830350112
Subject(s) - prolymphocytic leukemia , recombinant dna , medicine , leukemia , immunology , virology , biology , chronic lymphocytic leukemia , genetics , gene
The patient was a 65 year old woman with a massive splenomegaly and no lymphoadenopathy. An electron microscopic study of the peripheral blood cells revealed that these cells were prolymphocytes with a single large nucleolus. Treatment with native and recombinant α‐interferon has produced an impressive reduction in spleen size and in the count of prolymphocytes.