Premium
Richter syndrome with two B cell clones possessing different surface immunoglobulins and immunoglobulin gene rearrangements
Author(s) -
Tohda Shuji,
Suzuki Toshiya,
Nagata Kaoru,
Kamiyama Takashi,
Imai Yasufumi,
Nara Nobuo,
Aoki Nobuo,
Morio Tomohiro
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830350108
Subject(s) - surface immunoglobulin , antibody , biology , lymphoma , immunoglobulin heavy chain , immunoglobulin gene , chronic lymphocytic leukemia , population , gene rearrangement , immunoglobulin light chain , malignancy , immunology , gene , leukemia , bone marrow , b cell , cancer research , microbiology and biotechnology , genetics , medicine , environmental health
A patient with two populations of B cell malignancy in the bone marrow is reported. One population consisted of mature small lymphocytes, expressing surface IgM + D, λ and proliferating very slowly. The other population consisted of abnormal large lymphoid cells, expressing surface IgM, K and proliferating actively. We considered the former as chronic lymphocytic leukemia cells and the latter as malignant lymphoma cells. Therefore, this case was considered as Richter syndrome. The analysis of immunoglobulin heavy chain gene rearrangement showed the different patterns between the two populations. It suggested that the two populations arose from the different origins. We discussed the genetic relationship between the two clones of Richter syndrome referring to other reported cases.