Development of 5q‐ myelodysplasia in a patient with sarcoidosis

Sarcoidosis has been observed in association with numerous blood dyscrasias including lymphoma, leukemia, and multiple myeloma. This report describes a patient with sarcoidosis and a refractory anemia whose bone marrow karyotype showed deletion of the long arm of chromosome 5, consistent with a myelodysplastic syndrome. Concurrent sarcoidosis and myelodysplasia may relate to the continued availability of cytokines as a consequence of repeated macrophage, T‐cell, and B‐cell interactions, with evolution to the 5q‐ abnormality. This association may merit specific attention in the future approach to the diagnostic evaluation in certain patients with sarcoidosis.