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Level and composition of fetal hemoglobin expression in normal newborn babies are not dependent on β cluster DNA haplotype
Author(s) -
Rochette Jacques,
Dodé Catherine,
Leturcq France,
Krishnamoorthy Rajagopal
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830340313
Subject(s) - fetal hemoglobin , cord blood , haplotype , fetus , hemoglobin , cluster (spacecraft) , biology , dna , umbilical cord , genetics , physiology , gene , genotype , pregnancy , biochemistry , computer science , programming language
Interindividual variations in the level and composition of fetal hemoglobin observed in 604 cord blood samples from normal white and nonwhite newborns, unlike those in adults, are not dependent on β gene cluster DNA haplotype. The data suggest that the mechanism(s) involved in the neonatal expression of Hb F is distinct from that at the adult stage.