Hb South milwaukee [β105 (G7) leu → Phe]: A newly‐identified hemoglobin variant with high oxygen affinity | Zendy

Honig George R. | Zendy; Divgi Ajit B. | Zendy

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Hb South milwaukee [β105 (G7) leu → Phe]: A newly‐identified hemoglobin variant with high oxygen affinity

Author(s) -

Honig George R.,

Divgi Ajit B.

Publication year - 1990

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830340308

Subject(s) - hemoglobin , hemoglobin variants , hemoglobin s , oxygen , chemistry , biochemistry , medicine , cell , organic chemistry , sickle cell anemia

Fifteen individuals among four generations of a family of English ancestry demonstrated elevated hemoglobin levels accompanied by leftward‐shifted whole blood oxygen equilibrium curves. Five of the affected family members have required phlebotomies for relief of symptoms attributable to erythrocytosis. An abnormal hemoglobin or globin chain could not be isolated, but 43% of the β chains of the affected individuals contained a Leu → Phe substitution at position 105 (G7). Oxygen equilibrium curves demonstrated a normal Bohr effect but decreased cooperativity.

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