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Structure of the granulocyte macrophage colony‐stimulating factor gene in patients with the myelodysplastic syndromes
Author(s) -
Boultwood Jacqueline,
Abrahamson Gail,
Buckle Veronica J.,
Rack Katrina,
Oscier David G.,
Wainscoat James S.
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830340215
Subject(s) - myelodysplastic syndromes , granulocyte macrophage colony stimulating factor , granulocyte , gene , chromosome , immunology , chromosome 7 (human) , cancer research , granulocyte colony stimulating factor , medicine , biology , genetics , cytokine , bone marrow , chemotherapy
DNA samples from 76 patients with the myelodysplastic syndromes, including 10 cases with a partial deletion of the long arm of chromosome 5 (5q‐), were examined for structural rearrangements of the granulocyte/macrophage colony‐stimulating factor (GM‐CSF) gene. No abnormalities were detected, indicating that structural aberrations of this gene are not a feature of the myelodysplastic syndromes.