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Cyclosporin for treatment of life‐threatening alloimmunization
Author(s) -
Tilly Hervé,
Azagury Michael,
Bastit Dominique,
Lallemand Anne,
Piguet Hubert
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830340118
Subject(s) - medicine , bone marrow failure , aplastic anemia , refractory (planetary science) , platelet , platelet transfusion , hematology , surgery , bone marrow , immunology , haematopoiesis , stem cell , genetics , physics , astrobiology , biology
Abstract We describe a 16‐year‐old girl with aplastic anemia who, 1 year after initial diagnosis, developed a refractory state to platelet transfusions due to alloimmunication and resulting in severe bleeding. Treatment with cyclosporin, initially prescribed as treatment of the bone marrow failure, resulted in prompt decrease in lymphocytotoxic antibodies, which paralleled a marked improvement in platelet recovery. To our knowledge, such a dramatic effect of cyclosporin on alloimmunization has not been previously reported and merits further attention.