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Recurrent spleen enlargement during cyclic granulocyte‐macrophage colony‐stimulating factor therapy for myelodysplastic syndrome
Author(s) -
Delmer A.,
Karmochkine M.,
Cadiou M.,
Gerhartz H.,
Zittoun R.
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830340117
Subject(s) - spleen , medicine , granulocyte macrophage colony stimulating factor , myeloid , colony stimulating factor , granulocyte colony stimulating factor , growth factor , immunology , granulocyte , chemotherapy , biology , cytokine , stem cell , haematopoiesis , receptor , genetics
A 65‐year‐old woman with refractory anemia with excess of blasts received sequential courses of granulocyte‐macrophage colony‐stimulating factor therapy (GM‐CSF) and low‐dose cytosine arabinoside. Each course of GM‐CSF induced a rapid and tremendous increase in leukocyte count as well as in spleen size, 111 indium chloride scanning suggested a myeloid metaplasia of the spleen. This observation suggests that in some patients the granulopoietic response to the myeloid growth factor stimulation may be predominant in the spleen.