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Effect of novel 1‐alkyl‐3‐hydroxy‐2‐methylpyrid‐4‐one chelators on uptake and release of iron from macrophages
Author(s) -
Brock Jeremy H.,
Licéaga Joan,
Arthur Helen M. L.,
Kontoghiorghes George J.
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830340106
Subject(s) - chelation , chemistry , mononuclear phagocyte system , transferrin , deferoxamine , biochemistry , macrophage , immune system , ferritin , pharmacology , immunology , medicine , in vitro , organic chemistry
Abstract The effect of several iron chelators on iron uptake and release by mouse peritoneal macrophages has been investigated. The 1,2‐dimethyl (L1) and 1‐ethyl‐2‐methyl (L1NEt) derivatives of 3‐hydroxypyrid‐4‐one markedly enhanced iron mobilisation from macrophages pulsed with 59 Fe‐transferrin‐antitransferrin immune complexes and were more effective than desferrioxamine, maltol, or mimosine. Release increased with increasing chelator concentration. None of the chelators donated significant amounts of iron to macrophages, and none showed any cytotoxic effect. The synthetic α‐ketohydroxypyridine chelators may therefore be active in removing iron from the reticuloendothelial system as well as from hepatocytes, and indeed may be superior to desferrioxamine.